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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Transplant Rev (Orlando). 2016 Aug 3;30(4):227–234. doi: 10.1016/j.trre.2016.07.005

Figure 1. Schematic of mechanisms of HSC-induced tolerance.

Figure 1

Donor HSCs home to the recipient thymus, where they integrate with recipient thymic cells and develop donor/recipient chimerism. The result of chimerism is that central tolerance mechanisms ensue allowing mature T cells to develop that can recognize donor antigens as self (tolerized). T cells that recognize donor antigens as foreign undergo apoptosis. T cells that escape to the periphery undergo peripheral tolerance mechanisms that result in either anergy (in the absence of costimulation) or apoptosis (in the presence of costimulation).