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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: J Allergy Clin Immunol. 2016 May 24;138(4):1222–1224.e2. doi: 10.1016/j.jaci.2016.05.007

Figure 1. Functional characterization of STAT3 mutations.

Figure 1

Wild type (WT) or mutant STAT3 allele transfected Cos-7 (A&B) or U3A (C) cells were assessed for pY(705)STAT3 by flow cytometry after stimulation with Oncostatin M or varying concentrations of IL-6. (D) Shows the electrostatic potential near the WT or mutated STAT3 residues and their DNA binding. Negative charge is shown in red, positive in blue.