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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: J Allergy Clin Immunol. 2016 Jul 15;138(4):1098–1107.e3. doi: 10.1016/j.jaci.2016.07.001

Figure 4. IL-22 is necessary for the early recruitment of neutrophils and the induction of Cxcl1, Cxcl2 and Cxcl3 expression.

Figure 4

A. Schematic of S. aureus infection in neutrophil depleted mice. B. Left, Neutrophils, identified as CD11b+ Gr1hi cells are shown in the tape stripped skin of isotype treated or anti-Ly6G treated mice. Right, Percentage of neutrophils in the two groups of mice (n=4/group). C. Bacterial CFUs enumerated from the skin biopsies of WT and neutrophil depleted mice. D. Left, Neutrophils quantified in the skin of WT or Il22-/- mice in unmanipulated skin and 24 hrs after tape stripping, n=4/group. E. Neutrophil numbers in skin were quantitated in WT and Il22-/- mice at indicated time points after tape stripping and following S. aureus infection (n=3/time-point). F. mRNA expression levels of chemokines Cxcl1, Cxcl2, Cxcl3 and Cxcl15 determined in unmanipulated and tape-stripped skin of WT or Il22-/- mice, n=4/group. Mean with SEM is shown *: p<0.05, **: p<0.01, ***: p<0.001