. Author manuscript; available in PMC: 2017 Oct 1.

Published in final edited form as: J Neurochem. 2016 Sep 27;139(2):270–284. doi: 10.1111/jnc.13770

Table 2. Effect of calpain inhibition upon paralysis and OKR in EAE-ON.

Treatment with 50 mg/kg SNJ 1945 from Day 9 post-induction until Day 25 reduces the incidence of paralysis and the maximum clinical score (0<5). There was not a significant association between the severity of paralysis and the severity of acuity loss within individual animals with EAE, regardless of treatment group. N =7 Control, 8 EAE, 5 EAE SNJ.

	Paralysis Incidence	Day of Paralysis Onset	Maximum Clinical Score	Relationship of Paralysis vs. Affected Eye OKR Sensitivity Loss (Adjusted R²)
Control-Vehicle	0%	n/a	n/a	n/a
EAE-Vehicle	75%	17 ± 0.4	4	0.007
EAE-50mg/kg SNJ 1945	20%	17	2	0.268