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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Mol Cell Neurosci. 2016 Aug 10;76:11–20. doi: 10.1016/j.mcn.2016.08.002

Figure 3. LTD is attenuated 48 hours post-HS.

Figure 3

A) Time course of eEPSC amplitude in CA1 pyramidal neurons with pairing protocol shows attenuation in LTD 48–72 hours post-HS (right) compared with control (left). Inserts are representative traces before and 30 min post-LFS. Lower panel shows the time course of access resistance during LTD recording period. B) Summarized eEPSC amplitude changes in slices before pairing and 30 min post-pairing for control and post-HS rats; n=6 slices/group, p=0.02 by t-test. C) Representative averaged field (f)EPSP traces recorded in CA1 pyramidal neurons from control (top left panel) and post-seizures (in vivo seizures at P10) (Top right panel). Time course of LFS induced fEPSP change shows attenuated LTD in slices from rats post-HS compared to controls (lower panel). D) Quantification of fEPSP slope percent change from pre-LFS averaged over minutes 55–60 post-LFS in slices taken 48–72 hours post-HS and from age-matched controls (n=6, p=0.006 by t-test). Slopes were significantly lower in controls than in post-HS slices. Data is represented as mean±SE.