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. Author manuscript; available in PMC: 2017 Dec 5.
Published in final edited form as: Gene. 2016 Aug 30;594(1):10–15. doi: 10.1016/j.gene.2016.08.039

Figure 2. PINCH interacts with ILK, Nck2, and Rsu1.

Figure 2

The N-terminal ANK repeat domain of ILK binds to the LIM1 domain of PINCH. Together with parvin, they form a ternary complex referred to as the IPP complex. Through the LIM4 domain, PINCH interacts with Nck2, which may link the integrin signaling pathway with the growth factor receptor signaling pathways. Except for ILK and Nck2, PINCH also contacts with other key factors such as Rsu1. The LIM5 domain of PINCH is responsible for the interaction with Rsu1.