Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Sep 30;6(9):e478. doi: 10.1038/bcj.2016.87

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

FAXDC2 enhances ERK phosphorylation and upregulates RUNX1 in TPA-induced K562 cells. (a) Cytosolic localization (left panel) of FAXDC2 was observed in 293T cells overexpressing Flag-Tagged FAXDC2 protein (red). Right panel depicts merged image of FAXDC2 together with nuclear DAPI staining (blue). Scale bar: 75 μm. (b) K562 cells transduced with control (Ctrl) or FAXDC2-overexpressing lentiviral vector were induced with TPA for indicated hours. The phosphorylation of ERK (p-ERK), ERK, Flag and the expression of RUNX1 were measured. HSC70 served as control. (c) Control (Ctrl) or FAXDC2 knockdown (shRNA#1 and shRNA#2) K562 cells were stimulated with TPA for hours as indicated. The phosphorylation of ERK (p-ERK), ERK and the expression of RUNX1 were measured by western blot.