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Silencing effectiveness across all genes. A ranked order of all silenced genes based on fold change—values below 0 correspond to down-regulation, and values over 0 to up-regulation. All together 81.5% of measurements displayed a down-regulation below 0.7 and 30.5% were significant (red columns). Down-regulation was insufficient in 18.5% of studies, 6.3% even delivered an up-regulation instead of lower expression.
