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. 2016 Sep 27;5(9):e366. doi: 10.1038/mtna.2016.66

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Copyright © 2016 Official journal of the American Society of Gene & Cell Therapy

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Correlation between study methods and silencing power. Selection of the cell line model had a marked effect on silencing efficiency (a), while utilization of different transfection methods or controls was not significant (b,c). There was no difference between cancer and noncancer studies (d). Protocols validating the silencing by Western-blot reached the highest reduction in the gene chip data as well (e). When comparing silencing for the same gene within independent experiments (n = 62 genes), only the cell line selection of had a significant effect (f). In each figure, lower fold change values correspond to better silencing efficiency.