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. 2016 Oct 11;6:35117. doi: 10.1038/srep35117

Table 2. Peak positions and assignments of major Raman bands observed in thyroid healthy and PTC tissues.

Healthy tissue peak position (cm−1) Classical PTC tissue peak position (cm−1) Follicular PTC tissue peak position (cm−1) Band attribution Reference
673     tryptophan (ring breathing) 15
    717 membrane phospholipids head (C-N); adenine; lipids (CN+ (CH3)3) 15
748 748 748 DNA 15
    851 proline&hydroxyproline (side chain vibration); tyrosine (ring breathing and Fermi doublet); glycogen 15,16
919     proline; hydroxyproline; glycogen; lactic acid 15
    957 carotenoids; phosphates νs(PO43−); cholesterol; quinoid ring in-plane deformation 15,16
971 971   ν(C-C) wagging 15
994     C-O ribose, C-C 15,16
1003 1003 1003 phenylalanine νs (C-C) 15,17
  1006 1006 carotenoids 15
1031     phenylalanine (δ(C-H) and C-H in-plane bending); protein (C-N stretching); carbohydrate residues of collagen 15,16
1086 1084 1089 ν(C-C) gauche; ν1(CO32−); ν3(PO43−); ν(PO2−); ν(C-C) skeletal of acyl backbone in lipid (gauche conform.) 15,16
1128 1128 1128 proteins (C-N stretching); carbohydrates (C-O stretching); ceramides; acyl backbone in lipid (trans conform., ν(C-C)) 15, 16, 17
1156 1156 1156 protein (stretching C-C and C-N) 15
1156 1156 1156 carotenoids 15
1172 1172 1172 δ(C-H), tyrosine 15
  1205   ν(C–C6H5); tryptophan; phenylalanine; adenine and tyrosine (ring breathing); amide III 16
1225     amide III (β sheet structure) 15
1234     a concerted ring mode 15
1239     amide III 15, 16
  1264 1264 lipids 15
1307 1307 1307 lipid and collagen (twisting, bending, wagging) 15
1337 1337 1337 C-H deformation (protein); amide III; glycine and proline side chain (CH2 wagging vibrations); adenine and guanine (ring breathing modes) 15
1360 1360 1360 tryptophan 15
1393 1393 1393 CH rocking 15
1424     lipid (CH2 scissoring); deoxyribose (B, Z-marker) 15
  1440/1442 1440/1442 CH, CH2 and CH3 deformation; cholesterol; triglycerides (fatty acids); lipids (CH2 scissoring and CH3 bending); collagen 15
1445     collagen (δ(CH2), δ(CH3) and CH2CH3 bending); phospholipids (δ(CH2), δ(CH3) and CH2CH3 bending); methylene (bending) 15
1450 1448/1452/1464 1448 CH2CH3, CH2 and CH deformation; ν(C-H); δ(CH2); methyl groups bending; methylene deformation; proteins (δ(CH) and δ(CH2)) 15
1498   1498 (C-C) stretching in benzenoid ring 15
  1516/1518 1516/1518 β-carotene ν(C-C); carotenoid (C-C and conjugated C = C stretching); porphyrin ν(C = C) 14
  1520 1520 (-C = C-) carotenoids 15
1545     C6-H deformation; tryptophan 15
1552     tryptophan ν(C = C); porphyrin ν(C = C) 15
1557   1557 tryptophan; porphyrin ν(C = C); amide II (ν(CN) and δ(NH)); COO− (tyrosine, amide II) 15
1584 1584 1584 phenylalanine δ(C-C); (C-C) olefinic stretching; hydroxyproline; acetoacetate; riboflavin; lipids 15, 16, 17
1602   1602 phenylalanine δ(C-C) 15
1638 1640   water (intermolecular bending and very weak and broad ν2) 15
1660 1660 1660 ν(C-C) cis; (C-C) groups in unsaturated fatty acids; fatty acids; lipids; ceramide backbone; amide I 15
  2852 2852 νs(CH2); lipids; fatty acids 15
2879     lipids and proteins (CH2 and CH) 15
  2888 2888 lipids and proteins (CH2 asymmetric stretching) 15
2931 2931 2931 CH2 asymmetric stretching 15
2936   2936 chain end CH3 symmetric band 15
  2960 2960 out-of-plane chain end asymmetric CH3 stretching 15
  3010 3010 unsaturated = CH stretching 15