Table 3. Univariate and Multivariate analysis of factors associated with overall survival.
| Variables | Univariate | Multivariate | ||
|---|---|---|---|---|
| P-value | HR | 95% CI | P-value | |
| Male/female | 0.5727 | |||
| Age (years)(≤50 vs. >50) | 0.3934 | |||
| Child-Pugh grade: A/B + C | 0.3738 | |||
| AFP (ng/ml)(≤400 vs. >400) | 0.3795 | |||
| HBV DNA: positive/negative | 0.8918 | |||
| Tumor size: ≤5/>5 cm | 0.3198 | |||
| Tumor number:single/multiple | 0.0356 | NA | NA | — |
| CD3+ T cells (≤21 vs. >21) | 0.3078 | |||
| CD4+ T cells (≤11 vs. >11) | 0.7978 | |||
| CD8+ T cells (≤11 vs. >11) | 0.3072 | |||
| FoxP3+ Tregs (≤3.2 vs. >3.2) | 0.0069 | NA | NA | — |
| FoxP3+ Tregs/CD4+ T cells ratio (≤0.30 vs. >0.30) | 0.0006 | 3.543 | 1.505–8.341 | 0.004 |
| FoxP3+ Tregs/CD8+ T cells ratio (≤0.33 vs. >0.33) | 0.0044 | NA | NA | — |
Univariate and multivariate analysis: Cox proportional hazards regression model.
AFP = Alpha Fetal Protein; HBV = Hepatitis B Virus; FOXP3 = Forkhead/Winged Helix Transcription Factor P3; HR = Hazard Ratio; NA = not adopted.