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. 2016 Oct 11;6:34865. doi: 10.1038/srep34865

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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In this experiment, UPR signaling pathway markers were assessed in the skin of Ptch1^+/−/SKH-1 mice treated either with vehicle or PAO (100 μg/mouse) for different time intervals (0–16 h). (A) Western blot analysis of ATF4 and CHOP in the skin tissue lysate of PAO-treated samples at 0 h, 8 h and 16 h. Histogram showing dentiometric analysis of western blots. (B) Immunohistochemical staining of ATF4 and CHOP. Arrows showing expression and nuclear translocation of ATF4 (B-I) and CHOP (B-II) in the PAO-treated skin sections.