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. 2016 Oct 11;6:34920. doi: 10.1038/srep34920

Figure 8. The TAR RNA is a critical element of HIC1 inhibitory activity.

Figure 8

Microglial cells were co-transfected with pLTR-luc in presence of TAT (lanes 2 to 6) with (lanes 3 and 6) or without HIC1 (lanes 1, 2, 4 and 5). The implication of the TAR element in the HIC1-mediated HIV-1 transcription was assessed by comparing HIC1 repressive activity in absence (lanes 1, 2 and 3) or presence of free TAR RNA (lanes 4, 5 and 6). 48-hours post-transfection, cells were lysed and luciferase activity measured. Values were normalized using renilla luciferase system.