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. 2016 Oct 11;6:35053. doi: 10.1038/srep35053

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Copyright © 2016, The Author(s)

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The uptake of Gd-NPs in the vulnerable carotid plaque was followed as function of time for signal intensity (A), and contrast enhancement (B). The calculated slopes of the washout were determined for Gd-DOTA (C, grey) and Gd-NPs (D, green). They were significantly different for vulnerable carotid plaques versus healthy carotids. L: left. R: right. HC: High cholesterol. For HC⁺⁺ animal, Gd-DOTA values were not determined due to movements during the acquisition. *P < 0.05, **P < 0.01 HC versus healthy NHP. ^$p < 0.05 for HC⁺⁺ left versus right carotid.