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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Expert Rev Neurother. 2016 May 13;16(8):915–926. doi: 10.1080/14737175.2016.1184086

Figure 1.

Figure 1

Relationship between inflammation and cerebrovascular disease. Inflammation closely accompanies the secondary cell death process which initiates within hours and may persist over days, weeks, months, and even years after the initial insult. Sequestration of inflammation can help to reduce the expansion of ischemic core and to rescue the penumbra/peri-impact. *We recognize that there are multiple secondary cell death pathways, but we focus on the inflammation pathway because of its wide therapeutic window, which is the main of this paper.