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. 2016 Oct 10;16:192. doi: 10.1186/s12872-016-0366-4

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Hemodynamic parameters and RV function in three groups. PADN reversed the development of PAH, demonstrated by the decrease of mPAP (a), PVR (b), PADP (c) and PASP (d). Meanwhile, PADN improved RV function, demonstrated by reduced mRVP (e), RVSP (f), RV/(LV + S) (g), ANP and BNP (h). # P < 0.05 compared with the control group in week 8. ‖P < 0.05 compared with the control group in week 8. $ P < 0.05 compared with the control group in week 14. & P < 0.05 compared with the control group in week 14. * P < 0.05 compared with the PADN group in week 14. ×P < 0.05 compared with the sham group in week 14. ÷ P < 0.05 compared to the control group. ∞P < 0.05 compared to the sham group