Table 1.
Changes in the hemodynamic parameters in three groups
| Control (n = 6) | Sham (n = 6) | PADN (n = 7) | |
|---|---|---|---|
| Heart beats/min | |||
| Week 0 Week 8 Week 14 |
147.71 ± 25.09 138.57 ± 22.87 134.43 ± 37.95 |
160.00 ± 17.06 157.70 ± 22.26 159.60 ± 23.81 |
158.67 ± 13.37 165.89 ± 10.75 159.67 ± 10.14 |
| PVR, Wood units | |||
| Week 0 Week 8 Week 14 |
3.08 ± 0.50 2.99 ± 0.46 2.57 ± 0.54 |
2.68 ± 0.52 6.47 ± 1.61* 7.72 ± 2.69* |
2.70 ± 0.78 5.18 ± 0.75**,*** 4.87 ± 1.13**,**** |
| mPAP, mmHg | |||
| Week 0 Week 8 Week 14 |
15.29 ± 2.24 16.87 ± 1.66 17.27 ± 2.77 |
14.40 ± 3.57 28.64 ± 4.22* 33.72 ± 5.76* |
14.56 ± 3.00 27.71 ± 1.72**,*** 25.94 ± 3.67**,**** |
| PADP, mmHg | |||
| Week 0 Week 8 Week 14 |
9.41 ± 2.62 11.02 ± 2.24 9.93 ± 2.71 |
8.70 ± 3.62 20.84 ± 4.72* 24.90 ± 6.10* |
9.56 ± 3.21 19.10 ± 2.37** 17.79 ± 3.58**,**** |
| PASP, mmHg | |||
| Week 0 Week 8 Week 14 |
27.96 ± 2.24 29.98 ± 2.29 32.24 ± 3.02 |
27.30 ± 3.80 45.22 ± 5.48* 52.14 ± 6.63* |
27.11 ± 4.70 46.40 ± 3.93** 43.70 ± 4.58**,**** |
| mRVP, mmHg | |||
| Week 0 Week 8 Week 14 |
10.49 ± 1.54 11.10 ± 1.68 11.93 ± 1.48 |
9.80 ± 3.19 14.96 ± 2.61* 18.52 ± 2.07* |
10.11 ± 2.20 14.89 ± 1.83** 15.25 ± 2.45***,**** |
| RVSP, mmHg | |||
| Week 0 Week 8 Week 14 |
32.01 ± 3.69 33.38 ± 3.35 36.06 ± 4.30 |
32.40 ± 7.03 49.06 ± 6.76* 55.84 ± 5.75* |
31.89 ± 6.45 50.00 ± 4.18** 46.40 ± 6.77**,**** |
| PAOP, mmHg | |||
| Week 0 Week 8 Week 14 |
4.57 ± 1.40 5.29 ± 2.14 6.00 ± 1.63 |
4.70 ± 1.64 6.20 ± 2.25 4.90 ± 2.02 |
4.89 ± 1.69 5.67 ± 2.83 5.89 ± 2.09 |
| CO, L/min | |||
| Week 0 Week 8 Week 14 |
3.39 ± 0.35 3.86 ± 0.84 4.40 ± 1.24 |
3.61 ± 0.84 3.55 ± 0.66 4.02 ± 1.10 |
3.69 ± 0.85 4.22 ± 0.77 4.18 ± 0.63 |
Values are mean ± SD. * P < 0.05 compared with the control group. ** P < 0.05 compared with the control group. *** P < 0.05 compared with value at week 14. **** P < 0.05 compared with the sham group
PVR pulmonary vessel resistance, mPAP mean pulmonary arterial pressure, PADP pulmonary arterial diastolic pressure, PASP pulmonary arterial systolic pressure, mRVP mean right ventricular pressure, RVSP right ventricular systolic pressure, PAOP pulmonary artery occlusion pressure, CO cardiac output