Table 2. Body weight, food intake and plasma lipids in apoE−/− mice fed a normal chow or high fat diet. Values are expressed as the mean±SD. **P<0.01, mice from model (HFD) group vs those on a chow diet (control group). #P<0.05, ##P<0.01 betulin treatment vs model (HFD) group.
Group | Body weight (g) | Food intake (g/d per 20 g bw) | TC (mmol/L) | LDL (mmol/L) | TG (mmol/L) |
---|---|---|---|---|---|
Control | 27.33±1.53 | 2.20±0.12 | 10.42±1.48 | 7.58±0.80 | 0.78±0.38 |
Model | 27.79±1.63 | 2.17±0.17 | 31.14±3.47** | 23.14±3.02** | 0.69±0.39 |
Atorvastatin | 26.33±2.52 | 2.43±0.36 | 15.19±4.01## | 10.23±2.85## | 0.48±0.18 |
Betulin (20 mg/kg) | 26.31±1.39 | 2.29±0.12 | 23.88±4.15## | 18.04±3.62# | 0.41±0.17 |
Betulin (40 mg/kg) | 26.17±1.63 | 2.30±0.14 | 21.36±3.16## | 16.75±2.77## | 0.33±0.17 |