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The CHOP activator LGH00168 inhibited the growth of A549 cells in vitro and lung tumor growth in vivo. (A) The chemical structure of LGH00168 analogs. (B) The induction of CHOP luciferase activities by LGH00168 analogs in HEK293 cells. (C) The anti-proliferative effects of LGH00168 on nine cancer cell lines derived from six different organs. (D) LGH00168 inhibited the growth of A549 tumor xenografts in nude mice. (E) LGH00168 inhibited tumor growth on A549 xenograft bearing mice.
