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Effect of ERK1/2 and NF-κB inhibitors on collagen formation in cardiac fibroblasts in response to glucose and angiotensin II (Ang II). ERK1/2 inhibitor U0126 (10 μmol/L) and NF-κB inhibitor JSH-23 (10 μmol/L) both markedly inhibited glucose (20 mmol/L)- and Ang II (10−7 mol/L)-induced fibronectin (FN), collagen-3 (Col-3A1) and collagen-4 (Col-4A1) expression in cardiac fibroblasts. Bar graphs represent data from 4 independent experiments. *P<0.05 vs glucose- or Ang II-group.
