Figure 11.

A proposed model illustrating the mechanism underlying LX2343-mediated Aβ production inhibition and Aβ clearance promotion. Aβ is produced from the sequential cleavage of APP by BACE1 and γ-secretase. It can be degraded using autophagy. LX2343 synergistically restrains Aβ production by both inhibiting APP cleavage through the inhibition of JNK-mediated APP^Thr668 phosphorylation and by suppressing BACE1 activity. In addition, LX2343, as a PI₃K inhibitor, enhances Aβ clearance by stimulating autophagy through PI₃K/AKT/mTOR pathway inhibition.