Figure 3.

LX2343 had no effects on non-amyloidogenic processing of APP. Western blotting and its quantification results demonstrated that LX2343 had no effects on ADAM10 in HEK293-APPsw and CHO-APP cells (A–D) (one-way ANOVA, Dunnett's multiple comparison test, n=3). Intracellular sAPPa level was evaluated using ELISA assay (E, F) (one-way ANOVA, Dunnett's multiple comparison test, n=3). GAPDH was used as loading control in Western blot assays. All data were obtained from three independent experiments and presented as means±SEM.