Table 3.

VEST‐Indel Performance Metrics

	Sensitivity	Specificity	Balanced accuracy
In‐frame cross validation	0.90	0.90	0.90
In‐frame testing	0.80	0.85	0.82
Frameshift cross validation	0.83	0.88	0.85
Frameshift testing	0.89	0.86	0.87

Training utilized 10‐fold cross validation and pathogenic variants from Human Gene Mutation Database 2014.3 and benign examples from Exome Sequencing Project (minor allele frequency in African Ancestry ≥ 0.01). The test set consisted of pathogenic examples from ClinVar and benign examples derived from pairwise genome alignments of human and cow, dog, horse, chimp, rhesus macaque, and rat.