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. 2015 Oct 26;18(1):100–103. doi: 10.1111/dom.12576

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© 2015 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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DOM-12576-FIG-0001-b — Oral glucose tolerance test and serum insulin concentrations in individuals with type 2 diabetes (T2DM). Blood glucose concentrations in 20 men with T2DM before and during an oral glucose tolerance test (OGTT) shown for (A) placebo versus 100 mg sitagliptin and (B) placebo versus 100 mg sitagliptin plus 60 mg dextromethorphan (DXM). (C) Serum insulin concentrations during the first 30 min after starting the OGTT after administration of placebo, 100 mg sitaglipin and 100 mg sitagliptin plus 60 mg DXM. Significance (*p < 0.05) was determined by a linear mixed model, with treatment as a fixed factor and subject as a random factor using untransformed endpoints. All values are means ± standard deviation.