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. 2015 Oct 23;138(6):1516–1527. doi: 10.1002/ijc.29881

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© 2015 The Authors International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Nude mouse xenograft study. SW48 and LS174T cells were transplanted into nude mice, and the mice were treated with PBS as a control, CTX (1 mg/100 μL), ZOL (0.2 µM), or the combination of CTX and ZOL. (a) The volumes of implanted tumors compared to controls (left: SW48, right: LS174T). (b) The weights of the resected tumors. (c) Evaluation of xenografts. The results of western blot analysis for caspase‐3 and cleaved caspase‐3 are shown. (d) Histological evaluation of the xenografts. The expression of Ki67 and apoptosis indicated by TUNEL are shown. (e) Analysis of the TUNEL assay. Numbers of TUNEL‐positive cells per field are indicated. (f) Ki67 index is indicated. *p < 0.05; **p ≤ 0.01. Error bars in (a), (b), (e) and (f) show standard division (SD).