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. 2015 Oct 8;26(2):184–187. doi: 10.1111/jon.12307

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© 2015 The Authors. Journal of Neuroimaging published by Wiley Periodicals, Inc. on behalf of American Society of Neuroimaging

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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(A) Two baseline gadolinium‐enhancing (Gd+) lesions (white boxes) not converting to chronic black holes (CBH). (B) Two baseline Gd+ lesions (white boxes); 1 converted to a CBH (black box). (C) and (D) Fingolimod versus untreated groups on (C) percent of baseline Gd+ lesions converting to CBH at follow‐up, and (D) percent of patients developing CBH.

Key for A/B: FLAIR: fluid‐attenuated inversion‐recovery; T1‐Post: T1‐weighted post‐contrast gadolinium scan. Key for C: Gd+/CBH+: baseline Gd+ lesions converting to CBH; Gd+/CBH‐: baseline Gd+ lesions not converting to CBH.