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. 2016 Oct 10;14:66. doi: 10.1186/s12958-016-0198-1

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Schematic illustration of the experiment design of this study. Untreated: mice that received no treatment; Lo-dose Ozagrel (Oza): mice treated with 12.5 μg/g Oza (low-dose); Hi-dose Oza: mice treated with 25 μg/g Oza (high-dose). Lo-dose PD: mice treated with 1 μg/g rat anti-mouse GPIbα polyclonal IgG antibody for platelet depletion (PD); Hi-dose PD: mice treated with 2 μg/g rat anti-mouse GPIbα polyclonal IgG antibody; Non-immune: received 1 μg/g non-immune (NI) rat anti-mouse IgG isotope-matched with the anti-GPIbα antibody See text on experiment protocol for more details