Table 2.

Selected published results of SRS (2000–2015) for the treatment of GH-secreting pituitary adenomas

Authors	Patients	Type	Dose	Follow-up	Tumor	Biochemical	Late toxicity (%)
		of SRS	(Gy)	(months)	control (%)	remission (%)	visual	hypopituitarism
Zhang et al., 2000 [84]	68	GK	31a	34	100	40	NA	NA
Izawa et al., 2000 [85]	29	GK	22.5a	26.4	93	41	0	0
Attanasio et al., 2003 [86]	30	GK	20a	46	100	23	0	6.3
Jane et al., 2003 [87]	64	GK	15a	> 18	100	36	0	28
Castinetti et al., 2005 [88]	82	GK	28.5a	49.5	100	17	1.2	16
Gutt et al., 2005 [89]	44	GK	23a	23	100	48	0	NA
Kobayashi et al., 2005 [90]	67	GK	18.9a	63.3	100	17	11.1	14.6
Jezkova et al., 2006 [91]	96	GK	35a	53.7	100	50 (44 at 5 years)	0	27.1
Voges et al., 2006 [66]	64	LINAC	16.5	54.3	97	37.5 (33 at 5 years)	1,4	12.3 (18 at 5 years)
Petit et al., 2007 [92]	22	Protons	20	75	95	59	0	38
Pollock et al., 2007 [93]	46	GK	20a	63	100	50 (60 at 5 years)	2.2	36
Roberts et al., 2007 [82]	9	CK	18–24a	25.4	100	44.4	0	33
Vik-Mo et al., 2007 [94]	61	GK	26.5a	66	100	38 (58 at 5 years)	0	23
Jagannathan et al., 2008 [95]	95	GK	22a	57	98	53	4.2	34
Losa et al., 2008 [96]	83	GK	21.5a	69	97.6	60 (52 at 5 years)	0	8.5 (11.8 at 5 years)
Ronchi et al., 2009 [97]	35	GK	20a	114	100	82 (46 at 10 years)	0	50
Wan et al., 2009 [98]	103	GK	21.4a	67.3	95.1	36.9	NA	1.7
Hayashi et al., 2010 [70]	25	GK	25a	36	100	40	0	0
Iwai et al., 2010 [99]	26	GK	20a	84	96	38 (17 at 5 years)	0	8
Castinetti et al., 2009 [100]	43	GK	26a	96	100	42,0	0	23
Poon et al., 2010 [101]	40	GK	29a	73.8	NA	17	0	11.4
Erdur et al., 2011 [102]	22	GK	23.8a	60	95,2	54,5	0	28.6
Sheehan et al., 2011 [36]	130	GK	24a	31	93	53	2.3	34
Sicignano et al., 2012 [37]	39	GK	25a	60	97.7	54	NA	12.3
Franzin et al., 2012 [103]	103	GK	22.5a	71	97,3	60.7 (57 at 5 years)	0	7.8
Liu et al., 2012 [104]	40	GK	21a	72	97,5	47,5	0	40
Zeiler et al., 2013 [105]	21	GK	14.2a	33	100	30	3.9	13.2
Yan et al., 2013 [106]	22	LINAC	23	98	95	68.2	0	22.7
Wilson et al., 2013 [107]	86	LINAC	20	66	96	18.6	1,2	19.8
Lee et al., 2014 [108]	136	GK	25a	61.5	98.5	65.4 (73.4 at 6 years)	3.7	31.6
Wattson et al., 2014 [109]	50	Protons	20	51.5	100	48 (49 at 5 years)	0	57 (62 at 5 years)
Bostrom et al., 2015 [110]	21	LINAC	20	96	97.1	23	5	46.4

SRS stereotactic radiosurgery, GK Gamma Knife, LINAC Linear Accelerator, CK CyberKnife, NA not assessed

^amarginal dose; ^1–3 fractions