Figure 5.

mRNA expression of myogenic genes in skeletal muscle cells. C2C12 myocytes were transfected with a negative control (CON), a miR-126 antisense oligonucleotide (anti-miR), or a miR-126 mimic (mimic). A) Fold changes of 80 genes associated with myogenesis or myopathy were measured with PCR array in CON and anti-miR pooled samples. B) Selected myogenic genes were validated after inhibition (anti-miR) and overexpression (mimic) of miR-126 in skeletal muscle cells. ^aP < 0.05 vs. CON, ^bP < 0.05 vs. anti-miR; n = 3/group.