Table 1.
Top regulated genes after exercise
| YNG |
OLD |
|||||
|---|---|---|---|---|---|---|
| Top upregulated |
Top downregulated |
Top upregulated |
Top downregulated | |||
| Gene | FC | Gene | FC | Gene | FC | |
| XIRP1 | 16.2 | RHOBTB1 | −3.1 | XIRP1 | 6.8 | — |
| TNFRSF12A | 15.1 | DDIT4 | −3.0 | PRKAG2 | 5.2 | — |
| ATF3 | 14.2 | PLEKHF1 | −2.9 | TNFRSF12A | 4.9 | — |
| FOS | 10.0 | SBK1 | −2.8 | EGR1 | 3.9 | — |
| RRAD | 9.4 | TLE1 | −2.6 | RRAD | 3.8 | — |
| CDKN1A | 7.0 | PFKFB3 | −2.6 | PPARGC1A | 3.6 | — |
| KBTBD5 | 6.5 | IL17D | −2.4 | CDKN1A | 3.5 | — |
| MYC | 6.4 | PITX2 | −2.4 | KBTBD5 | 3.4 | — |
| IFRD1 | 6.2 | DDIT4L | −2.3 | MYC | 3.0 | — |
| HBEGF | 6.1 | IRS1 | −2.2 | ASB5 | 2.9 | — |
| PDK4 | 6.0 | FBXO32 | −2.2 | GADD45A | 2.8 | — |
Muscle biopsies were taken from the vastus lateralis of YNG and OLD men after an overnight fast, at rest (BL), and at 6 h after a single bout of high-intensity RE. Top up- and down-regulated genes at 6 h (vs. BL) expressed ≥±2-fold are presented for YNG and OLD men; n = 8/age group. FC, fold change.