Table 2.
Comparison analysis of gene expression changes
| YNG |
OLD |
||||
|---|---|---|---|---|---|
| IPA pathway | P | Genes (n) | IPA pathway | P | Genes (n) |
| Molecular and cellular functions | |||||
| Cellular growth and proliferation | 2.67E-17–1.63E-05 | 115 | Cellular development | 3.30E-12–1.56E-03 | 29 |
| Cell death and survival | 3.68E-16–1.63E-05 | 115 | Cellular growth and proliferation | 3.30E-12–1.46E-03 | 29 |
| Cellular development | 1.12E-13–1.63E-05 | 113 | Cell cycle | 9.73E-12–1.61E-03 | 24 |
| Cellular movement | 2.56E-13–1.58E-05 | 76 | Cell death and survival | 3.41E-08–1.38E-03 | 31 |
| Cell cycle | 9.77E-12–1.05E-05 | 56 | Lipid metabolism | 2.25E-07–1.60E-03 | 18 |
| Physiological system development and function | |||||
| Tumor morphology | 1.12E-13–1.22E-05 | 43 | Connective tissue development and function | 3.30E-12–1.55E-03 | 20 |
| Connective tissue development and function | 1.92E-12–1.15E-05 | 71 | Cardiovascular system development and function | 9.08E-08–1.56E-03 | 20 |
| Organismal survival | 7.16E-12–1.85E-07 | 83 | Organismal development | 9.08E-08–1.36E-03 | 25 |
| Tissue morphology | 1.97E-11–1.58E-05 | 74 | Tissue development | 1.35E-07–1.36E-03 | 23 |
| Cardiovascular system development and function | 2.19E-11–1.63E-05 | 65 | Tumor morphology | 2.38E-07–1.01E-03 | 17 |
| Top canonical pathways | |||||
| Hepatic fibrosis/hepatic stellate cell activation | 5.85E-06 | 11/155 (0.071) | Glucocorticoid receptor signaling | 8.74E-04 | 9/299 (0.03) |
| Role of tissue factor in cancer | 7.55E-06 | 10/130 (0.077) | PXR/RXR activation | 1.03E-03 | 3/92 (0.033) |
| Ilk signaling | 1.52E-05 | 13/205 (0.063) | IL-17 signaling | 1.07E-03 | 3/75 (0.04) |
| P38 MAPK signaling | 7.76E-05 | 8/120 (0.067) | Xenobiotic metabolism signaling | 1.24E-03 | 6/304 (0.02) |
| Igf-1 signaling | 1.68E-04 | 8/107 (0.075) | Acute myeloid leukemia signaling | 1.3E-03 | 3/84 (0.036) |
Comparison analysis of functional and canonical pathways with IPA reveals the disparities of transcriptional regulation between YNG and OLD men at 6 h after an acute bout of high-intensity RE. Italics denote relevant pathways.