Table 3.

miRNA expression profile of human subjects

miRNA	BL		Postexercise (6 h)
	OLD vs. YNG		OLD vs. BL		YNG vs. BL
	FC	P	FC	P	FC	P
miR-1	0.58 ↓	0.022	1.04	ND	1.72	ND
miR-10b-5pa	0.45 ↓	0.042	1.04	ND	1.26	ND
miR-16-5p	0.81	ND	0.66	ND	0.61 ↓	0.086
miR-23b-3p	0.82	ND	0.83	ND	0.54 ↓	0.004
miR-24-3p	0.84	ND	0.79	ND	0.38 ↓	0.002
miR-25-3p	0.56 ↓	0.084	0.65	ND	1.14	ND
miR-26a-5pa	0.47 ↓	0.071	1.62	ND	0.45 ↓	0.021
miR-26b-5pa	0.71	ND	0.88	ND	0.55 ↓	0.007
miR-27a-3p	1.06	ND	0.75	ND	0.45 ↓	0.001
miR-27b-3p	1.15	ND	0.81	ND	0.48 ↓	0.023
miR-29a-3p	1.58	0.118	1.06	ND	0.53 ↓	0.062
miR-29c-3p	1.33	ND	1.18	ND	0.52 ↓	0.020
miR-30a-5pa	0.66 ↓	0.090	0.83	ND	0.50 ↓	<0.001
miR-30d-5p	0.77	ND	0.83	ND	0.51 ↓	0.002
miR-30e-3p	0.58 ↓	0.020	0.89	ND	0.86	ND
miR-95-3p	0.87	ND	0.96	ND	0.56 ↓	0.042
miR-98-5p	0.36 ↓	0.067	1.11	ND	1.10	ND
miR-107a	0.84	ND	1.09	ND	0.62 ↓	0.065
miR-124-3p	0.58 ↓	0.007	0.84	ND	1.92	ND
miR-125a-5pa	0.65 ↓	0.038	0.83	ND	0.76	ND
miR-125b-5pa	0.63 ↓	0.043	0.92	ND	1.74	ND
miR-126-3pa	0.56 ↓	0.056	0.84	ND	0.39 ↓	0.005
miR-133a	0.88	ND	1.08	ND	0.44 ↓	0.042
miR-133b	0.80	ND	1.07	ND	0.39 ↓	0.027
miR-140-3p	0.94	ND	0.86	ND	0.65 ↓	0.016
miR-143-3pa	0.53 ↓	0.049	0.88	ND	0.68	0.111
miR-181a-5p	0.87	ND	1.35	ND	0.53 ↓	0.011
miR-193a-3pa	0.48 ↓	<0.001	1.07	ND	3.10	ND
miR-199a-3p	0.57 ↓	0.025	0.88	ND	1.27	ND
miR-208b-3p	0.62 ↓	0.077	1.06	ND	1.10	ND
miR-223-3p	0.66 ↓	0.066	1.52	ND	5.42	0.137
miR-324-3p	0.36 ↓	0.004	1.39	ND	0.53 ↓	0.079
miR-330-3p	0.63 ↓	0.015	0.86	ND	2.81	0.191
miR-335-5p	0.54 ↓	0.058	0.89	ND	1.96	ND
miR-378a-5p	0.61 ↓	0.029	0.78	ND	0.40 ↓	0.002
miR-423-3p	0.55	ND	1.14	ND	0.33	ND
miR-423-5p	1.04	ND	1.25 ↑	0.053	2.05 ↑	0.023
miR-486-5p	0.74 ↓	0.037	0.8512	ND	0.87	ND
miR-499-3p	0.54 ↓	0.006	0.982	ND	1.61	ND
let-7f-5p	0.51 ↓	0.058	0.8526	ND	1.19	ND

Muscle biopsies were taken from the vastus lateralis of YNG men at rest after an overnight fast and at 6 h after a single bout of high-intensity RE. miRNA expression at BL in OLD men and at 6h after RE in OLD and YNG men. FC, fold change; ↑, upregulated; ↓, downregulated; ND, no difference.

^aClustered miRNA in miR factor analysis; n = 8/age group.