Table 6.
KEGG pathways associated with miR factor 1 clustered with PCA
| KEGG pathway | P | Genes (n) | miRNAs (n) |
|---|---|---|---|
| Ubiquitin-mediated proteolysis | 1.96E-18 | 55 | 9 |
| Regulation of actin cytoskeleton | 2.33E-12 | 70 | 10 |
| Focal adhesion | 3.15E-12 | 66 | 10 |
| MAPK signaling pathway | 3.12E-11 | 81 | 10 |
| Wnt signaling pathway | 9.10E-11 | 55 | 9 |
| PI3K-Akt signaling pathway | 1.94E-10 | 97 | 10 |
| mRNA surveillance pathway | 1.33E-09 | 34 | 9 |
| Transcriptional misregulation in cancer | 5.28E-09 | 61 | 10 |
| TGF-β signaling pathway | 9.40E-09 | 30 | 8 |
| mTOR signaling pathway | 2.61E-07 | 24 | 10 |
| ErbB signaling pathway | 1.07E-06 | 32 | 10 |
| Insulin signaling pathway | 1.24E-06 | 42 | 10 |
| Type II diabetes mellitus | 3.57E-05 | 17 | 8 |
| VEGF signaling pathway | 0.000382 | 21 | 9 |
| p53 signaling pathway | 0.000559 | 22 | 10 |
| Basal transcription factors | 0.000731 | 15 | 9 |
| Adipocytokine signaling pathway | 0.005166 | 20 | 8 |
| Cell cycle | 0.005487 | 35 | 10 |
| Phosphatidylinositol signaling system | 0.008304 | 26 | 9 |
| HIF-1 signaling pathway | 0.024575 | 29 | 9 |
| Chemokine signaling pathway | 0.045806 | 44 | 10 |
Identification of relevant KEGG pathways regulated by 10 miRNAs clustered into miR factor 1 as determined with PCA and identified with DIANA-miRPath 2.0 using experimentally verified targets from TarBase 6.0. Italics denote relevant pathways.