Table 2.
Association of DDR1 and DDR2 (low 1–2, high 3–4) with clinical and pathologic characteristics
| Characteristic | DDR1 (N=190)
|
DDR2 (N=197)
|
||||
|---|---|---|---|---|---|---|
| LOW | HIGH | p-value* | LOW | HIGH | p-value* | |
| Menopausal Status | 0.17 | 0.63 | ||||
| Pre | 20 (46.5) | 23 (53.5) | 19 (44.2) | 24 (55.8) | ||
| Peri | 6 (37.5) | 10 (62.5) | 5 (33.3) | 10 (66.7) | ||
| Post | 68 (58.1) | 49 (41.9) | 58 (46.4) | 67 (53.6) | ||
| Tumor Size (cm) | 0.60 | 0.39 | ||||
| ≤2 | 53 (53.5) | 46 (46.5) | 48 (48.0) | 52 (52.0) | ||
| >2 | 42 (57.5) | 31 (42.5) | 32 (41.6) | 45 (58.4) | ||
| Tumor Grade | 0.15 | 0.002 | ||||
| I or II | 47 (61.8) | 29 (38.2) | 46 (56.1) | 36 (43.9) | ||
| III | 52 (51.0) | 50 (49.0) | 34 (33.0) | 69 (67.0) | ||
| Estrogen Receptor | 0.78 | |||||
| Positive | 48 (55.8) | 38 (44.2) | 54 (59.3) | 37 (40.7) | <0.0001 | |
| Negative | 50 (53.8) | 43 (46.2) | 27 (28.4) | 68 (71.6) | ||
| Progesterone Receptor | 0.13 | 0.0005 | ||||
| Positive | 43 (61.4) | 27 (38.6) | 44 (59.5) | 30 (40.5) | ||
| Negative | 55 (50.0) | 55 (50.0) | 38 (33.6) | 75 (66.4) | ||
| HER2/neu Status | 0.18 | 0.011 | ||||
| Overexpressed | 8 (40.0) | 12 (60.0) | 4 (19.0) | 17 (81.0) | ||
| Not overexpressed | 95 (55.9) | 75 (44.1) | 83 (47.2) | 93 (52.8) | ||
| LVI | 0.49 | 0.93 | ||||
| Present | 30 (50.8) | 29 (49.2) | 26 (43.3) | 34 (56.7) | ||
| Absent | 67 (56.3) | 52 (43.7) | 55 (44.0) | 70 (56.0) | ||
| Lymph Nodes | 0.82 | 0.32 | ||||
| Negative | 45 (52.3) | 41 (47.7) | 38 (43.2) | 50 (56.8) | ||
| Positive | 39 (54.2) | 33 (45.8) | 27 (35.5) | 49 (64.5) | ||
*
Chi-square test of independence or Fisher’s exact without unknown category