Figure 6.

Alignment of further humanized RK35 constructs CDR regions to the murine and germline sequences. Gray lettering is used for residues that are the same in mouse and human sequence, black lettering is used where the murine amino acid is different from the human germline, green are residues predicted to be acceptable to germline to human, red are residues predicted to be not acceptable to germline and blue residues are likely acceptable, but not all prediction methods agree.