Table 7.

Analysis of Stability Prediction Method.

	Discovery Studio
Prediction	Des	Tol
Destabilizing	482	83
Tolerated	239	217
Fraction Correct	0.67	0.72
Fraction Destabilizing	0.85	0.15
Fraction Tolerated	0.52	0.48

The table shows total number of destabilizing (Des) and tolerated (Tol) mutants found in each prediction group for the Discovery Studio stability prediction method. The Fraction correct is the true positive rate for destabilizing predictions and true negative rate for Tolerated predictions. The fraction destabilizing and fraction tolerated are the number of experimentally determined destabilizing and tolerated mutants in that group divided by the total number of destabilizing or tolerated mutants, respectively.