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Affinities of CA645 Fab graft variants gL4gH5 and gL5gH5 for HSA and MSA. Association (ka) and dissociation (kd) rate constants and equilibrium binding constants (KD) determined by SPR.
| CA645 graft variants | Albumin species | ka x104 (1/Ms) | kd x10−4 (1/s) | KD x10−9 (M) |
|---|---|---|---|---|
| gL4gH5 | HSA | 22 | 4.0 | 1.8 |
| gL4gH5 | MSA | 31 | 6.8 | 2.2 |
| gL5gH5 | HSA | 8.5 | 220 | 254 |
| gL5gH5 | MSA | 1.2 | 38 | 316 |
