Fig. 3.

IL-1β blockade results in diminished pulmonary bacterial growth and dissemination.

Wild-type mice (n = 7–8/group) were infected with B pseudomallei intranasally and received PBS or were treated postinfection with either ceftazidime (CAZ), anti-IL-1β antibody, or both, starting 6 h postinfection. At 24 and 72 h after bacterial inoculation mice were sacrificed. Blood and organs were harvested and plated on blood-agar plates to determine bacterial counts in lung (A), blood (B), and liver (C). Data are presented as means ± SEM. ^∗P <0.05; ^∗∗P <0.01; ^∗∗∗P <0.001 versus controls. BC+ denotes blood culture positivity (Kruskal–Wallis test, followed by separate Mann–Whitney U tests).