Table 1.

Relative copy numbers of monocyte and granulocyte mRNA of healthy controls and melioidosis patients

	Controls (n = 32)		Patients (n = 34)
	Granulocytes	Monocytes	Granulocytes	Monocytes
Caspase-1	1.04 ± 0.20	0.89 ± 0.11	0.85 ± 0.43	0.54 ± 0.07*
NLRP3	1.06 ± 0.19	1.27 ± 0,25	0.60 ± 0.13*	0.51 ± 0.09**
ASC	1.23 ± 0.25	1.28 ± 0.28	0.46 ± 0.10*	0.42 ± 0.06*

Granulocyte and monocyte mRNA expression levels were determined in healthy controls and patients with culture-proven melioidosis. Thirty-four septic melioidosis patients (17 males) and 32 healthy control subjects (22 males) were enrolled. The mean ages were 52 years (18–86 years) and 41 years (21–59 years) for patients and controls, respectively. Blood cultures were positive for B pseudomallei in 21 patients (61.7%). After inclusion all patients received appropriate antimicrobial therapy. The overall in-hospital patient mortality was 44% (14).

Shown are monocyte and granulocyte mRNA expression levels (normalized for GAPDH). Data are expressed as mean ± SEM and analyzed by Mann–Whitney U test.

^*P <0.05.

^**P <0.01 compared with controls (Mann–Whitney U test).