Table 2. Aging biomarker results at baseline (T0), 3 months (T1), and 1 year (T2), and their differential evolution over time in Chemo and Control Groups.

	Chemo Group (n=57)			Evolution Over Time Chemo Group		Control Group(n=52)			Evolution Over Time Control Group		Differential Evolution Chemo and Control (TimeInteraction)
	T0	T1	T2	T0 → T1	T0 → T2	T0	T1	T2	T0 → T1	T0 → T2
LTL N T/S mean +/− SD	45 0.7 +/− 0.2	46 0.7 +/− 0.3	49 0.6 +/− 0.2	p=0.05 p =0.05	p<0.01 p <0.01	41 0.7 +/−0.3	45 0.6 +/−0.15	44 0.6 +/−0.14	p=0.02 p =0.02	p<0.01 p <0.01	p=0.88 p=0.87
IL-6 N pg/mL mean +/− SD	56 3.2 +/− 3.7	55 2.3 +/− 3.7	51 4.5 +/− 9.2	p=0.02 p =0.02	p=0.27 p =0.26	52 7.0 +/−13.9	48 11.4 +/−38.5	46 5.6 +/−6.1	p=0.95 p=0.77	p=0.66 p=0.45	p<0.01 p <0.04
IL-10 N pg/mL mean +/− SD	51 0.3+/− 0.4	50 0.3 +/− 0.3	47 0.2 +/− 0.1	p=0.05 p =0.01	p<0.01 p <0.01	50 0.2 +/−0.2	47 0.2 +/−0.2	46 0.2 +/−0.1	p=0.92 p=0.96	p=0.28 p=0.23	p<0.01 p <0.01
TNF-alpha N pg/mL mean +/− SD	56 2.5 +/− 10.1	55 2.9 +/− 9.7	51 3.3 +/− 9.6	p<0.01 p <0.01	p<0.01 p <0.01	52 2.3 +/−3.1	48 2.5 +/−3.4	46 2.5 +/−3.1	p=0.71 p=0.71	p=0.08 p=0.06	p<0.01 p =0.01
MCP-1 N pg/mL mean +/− SD	55 143 +/− 70	55 110.7 +/− 70	51 183.2+/− 48	p<0.01 p <0.01	p<0.01 p <0.01	52 189 +/−78	48 219 +/−131	46 207 +/−108	p=0.14 p=0.16	p=0.34 p=0.29	p<0.01 p <0.01
Rantes N pg/mL mean +/− SD	55 59562+/− 46691	55 61411+/− 53735	51 51903+/− 47600	p=0.78 p=0.83	p=0.01 p =0.01	52 59004 +/−43436	48 53215 +/−46461	46 55421 +/−48231	p=0.03 p =0.03	p=0.03 p=0.03	p=0.29 p=0.28
IGF-1 N ng/mL mean +/− SD	55 79 +/− 26	54 67 +/− 26	51 70 +/− 24	p<0.01 p <0.01	p<0.01 p <0.01	51 76 +/−36	48 77 +/−27	46 74 +/−34	p=0.31 p=0.35	p=0.48 p=0.64	p<0.01 p <0.01

Abbreviations. SD: Standard Deviation; CI: Confidence Interval; LTL: Leukocyte Telomere Length; IL-6: Interleukin-6; IL-10: Interleukin-10; TNF-alpha: Tumor Necrosis Factor Alpha; MCP-1: Monocyte Chemotactic Protein 1; RANTES: Regulated Upon Activation, Normal T cell Expressed and presumably Secreted; IGF-1: Insulin Like Growth Factor 1