Table 3. Geriatric assessment results at baseline (T0), 3 months (T1), and 1 year (T2), and their differential evolution over time in Chemo and Control Groups.
| Chemo Group (n=57) | Evolution Over Time Chemo Group | Control Group (n=52) | Evolution Over Time Control Group | Differential Evolution (Time Interaction) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| T0 | T1 | T2 | T0 → T1 | T0 → T2 | T0 | T1 | T2 | T0 → T1 | T0 → T2 | ||
| Frailty(Balducci) N Fit n (%) Vulnerable n (%) Frail n (%) |
56 12 (21) 21 (35) 23 (41) |
53 8 (15) 23 (43) 22 (42) |
48 10 (21) 15 (31) 23 (48) |
p=0.87 |
p=0.41 |
52 10 (19) 17 (33) 25 (48) |
48 9 (19) 13 (27) 26 (54) |
46 7 (15) 13 (28) 26 (57) |
p=0.34 |
p=0.77 |
p=0.63α |
| LOFS N Mean +/− SD |
56 7.5 +/− 2 |
53 6.7 +/− 2 |
48 7.4 +/− 2 |
p<0.01 | p=0.60 | 51 6.8 +/− 2 |
48 7.0 +/− 2 |
46 6.8 +/− 2 |
p=0.48 |
p=0.45 |
p<0.01 |
| ADL N Mean +/− SD 6§ n (%) 0-5 n (%) |
56 5.5 +/− 1 33 (59) 23 (41) |
56 5.4 +/− 1 35 (62) 21 (37) |
51 5.5 +/− 1 30 (59) 21 (41) |
p=0.88 p=0.88 |
p=0.96 p=0.99 |
52 5.1 +/− 1 29 (56) 23 (44) |
48 5.0 +/− 1 23 (48) 25 (52) |
46 5.0 +/− 1 21 (46) 25 (54) |
p=0.94 p=0.85 |
p=0.57 p=0.47 |
p=0.77 p=0.76 |
| IADL N Mean +/− SD 8§ n (%) 0-7 n (%) |
57 6.6 +/− 2 24 (42) 33 (58) |
56 6.0 +/− 2 16 (29) 40 (71) |
51 6.8 +/− 2 26 (51) 25 (49) |
p<0.01 p=0.01 |
p=0.39 p=0.39 |
52 5.8 +/− 2 17 (33) 35 (67) |
48 5.8 +/− 2 17 (35) 31 (65) |
46 5.7 +/− 3 17 (37) 29 (63) |
p=0.71 p=0.75 |
p=0.57 p=0.60 |
p<0.01 p=0.01 |
| Previous falls N No n (%) Yes n (%) |
57 44 (77) 13 (23) |
N/A | 50 34 (68) 16 (32) |
N/A |
p=0.28 p=0.25 |
52 28 (54) 24 (46) |
N/A | 46 29 (63) 17 (37) |
N/A |
p=0.33 p=0.37 |
p=0.15β p=0.15 β |
| MMSE N Mean +/− SD |
57 27.9 +/− 2 |
56 27.6 +/− 3 |
51 27.9 +/− 3 |
p=0.22 p=0.19 |
p=0.94 p=0.96 |
52 27.9 +/− 2 |
48 27.8 +/− 3 |
46 27.9 +/− 4 |
p=0.34 p=0.31 |
p=0.40 p=0.41 |
p=0.77 p=0.78 |
| GDS-15 N Mean +/− SD 0-4§ n (%) 5-15 n (%) |
55 2.9 +/− 2 46 (84) 9 (16) |
56 3.1 +/− 2 43 (77) 13 (23) |
50 3.1 +/− 3 38 (76) 12 (24) |
p=0.31 p=0.23 |
p=0.50 p=0.51 |
46 2.8 +/− 2 35 (76) 11 (24) |
47 3.5 +/− 3 32 (68) 15 (32) |
45 3.1 +/− 3 35 (78) 10 (22) |
p=0.23 p=0.25 |
p=0.40 p=0.40 |
p=0.98 p=0.98 |
| MNA-SF N Mean +/− SD ≥ 12§ n (%) < 11 n (%) |
57 11.1 +/− 2 25 (44) 32 (56) |
55 9.9 +/− 2 16 (29) 39 (71) |
50 11.5 +/− 2 27 (54) 23 (46) |
p<0.01 p<0.01 |
p=0.19 p=0.13 |
51 11.0 +/− 2 23 (45) 28 (55) |
48 11.3 +/− 2 29 (60) 19 (40) |
46 11.4 +/− 2 23 (50) 23 (50) |
p=0.24 p=0.32 |
p=0.23 p=0.21 |
p<0.01 p<0.01 |
| CCI N Mean +/− SD 0§ n (%) 1 n (%) >=2 n (%) |
54 0.6 +/− 1 32 (59) 12 (22) 10 (19) |
53 0.7 +/− 1 32 (60) 10 (19) 11 (21) |
49 0.7 +/− 1 28 (57) 12 (25) 9 (18) |
p=0.42 p=0.48 |
p=0.16 p=0.78 |
52 1.1 +/− 2 27 (52) 12 (23) 13 (25) |
50 1.1 +/− 2 27 (54) 10 (20) 13 (26) |
46 1.2 +/− 2 22 (48) 11 (24) 13 (28) |
p=0.86 p=0.97 |
p=0.35 p=0.91 |
p=0.63θ p=0.86 θ |
| G8 N Mean +/− SD >14 n (%) ≤ 14 n (%) |
56 14.2 +/− 2 28 (50) 28 (50) |
NA | NA | N/A | N/A | 52 13.7 +/− 2 22 (42) 30 (58) |
NA | NA | N/A | N/A | N/A |
| Global QoL N Mean +/− SD |
57 64.2 +/− 17 |
56 58.5 +/− 20 |
50 69.5 +/− 22 |
p=0.06 p=0.05 |
p=0.11 p=0.08 |
52 63.8 +/− 17 |
48 64.6 +/− 20 |
46 63.6 +/− 23 |
p=0.83 p=0.83 |
p=0.73 p=0.96 |
p=0.02 p=0.03 |
Abbreviations. SD: Standard Deviation; CI: Confidence Interval; ADL: Activities of Daily Living; IADL: Instrumental Activities of Daily Living; MMSE: Mini Mental State Examination; GDS: Geriatric Depression Scale; MNA-SF: Mini Nutritional Assessment-Short Form; MNA: Mini Nutritional Assessment
§: Maximum score, no abnormalities
α: calculation based on probability of being fit or vulnerable by time and study arm
β: calculation based on probability of falling by time and study arm
θ: calculation based on probability of having the lowest score at CCI, by time and study arm
p-values in italic font show results corrected for patient frailty level at baseline