Table 3. The ten most frequently mutated genes in our patient cohort.
| Gene | No. of mutations | No. of mutated patients | % mutated patients (n = 185) |
|---|---|---|---|
| TET2 | 78 | 53 | 28.7% |
| SRSF2 | 36 | 36 | 19.5% |
| ASXL1 | 16 | 16 | 8.6% |
| U2AF1 | 15 | 15 | 8.1% |
| TP53 | 14 | 14 | 7.6% |
| JAK2 | 13 | 13 | 7.0% |
| SETBP1 | 12 | 12 | 6.5% |
| RUNX1 | 11 | 11 | 5.9% |
| DNMT3A | 10 | 10 | 5.4% |
| EZH2 | 11 | 9 | 4.9% |
TET2 show more than one variant in 24 patients. NRAS and EZH2 show two mutations in two patients. CSF3R show more than one variant in one patient. (NRAS and CSF3R are not among the ten most frequently mutated genes).