Table 3. Cases with secondary mutations developed under Imatinib therapy.
| Primary tumor | Metastasis | |||||
|---|---|---|---|---|---|---|
| Site | Gene/exon | Mutation | Site | Gene/exon | Mutation | |
| 1 | NA | KIT/11 | Met552_Pro573delinsIle | abdominal cavity | KIT/17 | Tyr823Asp |
| 2 | stomach | KIT/11 | Trp557_Glu561del | abdominal cavity | KIT/13 | Val654Ala |
| 3 | NA | KIT/11 | Asn566_Pro573del | abdominal cavity | KIT/17 | Asn822Lys |
| 4 | duodenum | KIT/11 | Val560_Leu576del | Liver | KIT/13 | Met651Ile |
| 5 | NA | KIT/11 | Glu556_Val560delinsHis | abdominal cavity | KIT/17 | Asn822Lys |
| 6 | stomach | KIT/13 | Lys642Glu | abdominal cavity | KIT/17 | Asn822Lys |
| 7 | stomach | KIT/13 | Lys642Glu | abdominal cavity | PDGFRA/18 | Arg841_Asp842delinsLys |