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. 2016 Feb 3;7(21):30258–30275. doi: 10.18632/oncotarget.7162

Figure 6. Decreased expression of Dicer in fresh ATL cells.

Figure 6

A-F. Relative expression of six genes related to miRNA biogenesis (drosha, DgCR8, exportin-5, dicer, ago2 and ago3) was measured by quantitative RT-PCR and normalized to HPRT RNA levels in CD8+-cell–depleted PBMCs from HTLV-1 asymptomatic carriers (AC) and patients with acute ATL (ATL). Significance difference in relative expression is indicated by asterisk (**p<0.01; ***p<0.001). G. Significant correlation between Dicer decreased expression and HBZ relative expression level was shown in ex vivo cultured cells from patients with acute ATL. Data showed HBZ and Dicer expression over 5 days of ex vivo culture (d0,d1,d3 and d5). Pearson's correlation coefficient was 0.9321 (p<0.01).