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. 2016 Apr 21;7(21):30610–30625. doi: 10.18632/oncotarget.8895

Figure 5. SKA2 is downstream target of miR-141.

Figure 5

(A) Predicted binding of miR-141 to the 3′UTR of human SKA2 by TargetScan. (B, C) miR-141 mimic repressed Luciferase activity of the wild but not the mutant 3′UTR of SKA2 reporter in U87 and U251 glioma cells. (D) SKA2 mRNA expression was downregulated after transfection with miR-141 mimic in U87 and U251 glioma cells. (E) miR-141 mimic decreased the expression of SKA2 protein in U87 and U251 glioma cells. The data represent the mean ± SD of three different experiments.*P < 0.05, **P < 0.01 versus scramble control.