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. 2016 Apr 15;7(21):30712–30729. doi: 10.18632/oncotarget.8750

Figure 1. Expression of SRC family kinases in multiple myeloma cells.

Figure 1

A. Chemical structure of saracatinib (4-Quinazolinamine, N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazin-1-yl)ethoxy]-5-(tetrahydro-2H-pyran-4-yloxy)-quinazolin-4-amine) (image source: selleckchem.com). B. SFK mRNA expression in patients (GSE6477 dataset, total n=162 patients): Normal (healthy controls, n=15), MGUS (monoclonal gammopathy of undetermined significance, n=21), smoldering MM (n=23), newly diagnosed MM (n=75) and relapsed MM (n=28)(upper panel, *: p<.0.05 versus normal). SFK protein levels in MM cell lines (proteinatlas.org, lower panel). N.D.: not determined. Y-axis is kept at 0-8000 to illustrate the protein expression range in cell types of different origin in the proteinatlas.org database.