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. 2016 Apr 23;7(21):30760–30771. doi: 10.18632/oncotarget.8953

Figure 2. Kaplan-Meier plots with prostate-specific antigen recurrence as end point.

Figure 2

Kaplan-Meier survival analysis of recurrence free survival (RFS) based on the 3-miRNA prognostic classifier (miR-185-5p+miR-221-3p+miR-326) in prostatectomy samples from three independent RP cohorts. Patients in the training RP cohort 1 (left) were divided into low vs. high risk groups after ROC analysis. Patients in validation RP cohort 2 (middle) were divided into low/high risk groups according to the cut-off (fraction) defined in RP cohort 1. This was done in the same way for the external validation RP cohort 3 (right). Significant P values for two-sided log-rank test are given. High molecular risk status, as defined by the 3-miRNA prognostic classifier (miR-185-5p+miR-221-3p+miR-326), was significantly associated with early biochemical recurrence after RP in three independent cohorts.