Table 3. Univariate and multivariate cox regression analyses estimating the associations of PD-1 and PD-L1 expression with patient survival.
| Crude HR | 95%CI | P-value | Adjust HR | 95%CI | P-value | |
|---|---|---|---|---|---|---|
| Disease free survival | ||||||
| PD-1 | ||||||
| Negative | 1.00 | 1.00 | ||||
| Positive | 0.99 | 0.68–1.43 | 0.951 | 0.94 | 0.64–1.37 | 0.737 |
| PD-L1 | ||||||
| Negative | 1.00 | 1.00 | ||||
| Positive | 0.75 | 0.56–1.00 | 0.048 | 0.80 | 0.55–1.17 | 0.249 |
| Overall survival | ||||||
| PD-1 | ||||||
| Negative | 1.00 | 1.00 | ||||
| Positive | 1.05 | 0.80–1.37 | 0.748 | 0.87 | 0.62–1.24 | 0.452 |
| PD-L1 | ||||||
| Negative | 1.00 | 1.00 | ||||
| Positive | 0.85 | 0.65–1.10 | 0.219 | 0.83 | 0.59–1.18 | 0.293 |
a
Associations determined by Cox proportional hazards regression and adjusted for age, sex, tumor site, stage, grade, smoking experience, alcohol drinking and family history.
b
Bold-italic values are statistically significant (p < 0.05).