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. 2016 Apr 18;7(21):30935–30950. doi: 10.18632/oncotarget.8817

Figure 3. EC-8042 downregulates the expression of ABC transporters and is not a substrate for them.

Figure 3

A. Relative mRNA expression of ABCG2, ABCB1 and ABCC1 genes in MSC-5H-GFP and MSC-5H-FC cells treated with the indicated concentrations of EC-8042 for 24 hours. B. ABCG2 and ABCB1 functional inhibition assay for EC-8042 and MTM. Cladribine/Ko243 and digoxin/valspodar were used as negative/positive control drugs for ABCG2 and ABCB1 respectively. C. ABCG2 and ABCB1 functional substrate assay for EC-8042 and MTM. Ko243 and valspodar were used as transporter inhibitors for ABCG2 and ABCB1 respectively. Error bars represents the standard error of the mean (SEM) and asterisks indicate a statistically significant difference with the respective control groups (*:p<0.05; two-sided Student t test).