Figure 4. The effect of stabilin-1 on tumor growth and infiltration of TS/A tumors by immune cells.
Wild type (wt) and stabilin-1 knockout (ko) mice were injected s.c. with 5×106 TS/A tumor cells. A. Tumor volume (mm3) in wt (n=12) and stabilin-1 ko (n=12) mice was measured 21 days after tumor cell inoculation. The data are presented as box plots with medians indicated, **p<0.01, Mann-Whitney U test. B. IHC analysis of TS/A tumors for the expression of CD31 (vascular marker), F4/80 (macrophage marker), CD3 (T cell marker) and Gr-1 (neutrophil marker) on day 21 after tumor cell inoculation. Representative images from 5 tumors are shown. Scale bars: 100 μm.